Your PR has to be officially removed by CIC to make you a non-PR again. This can be due to not satisfying the residency obligation (RO) AND that the CIC actually finds out and initiates removal proceedings, after which you can appeal this decision a number of time. PR doesn’t “expire” on it’s own if you satisfy RO (2/5), so there’s no concept of “utilizing” the PR.
If you commit a crime or engage in illegal activity or CIC finds out you misrepresented in your PR application then your PR can be nullified.
If you renounce your PR for whatever reason then that’s the quickest way to lose your PR.
You can always apply for PR again if you lose your PR.