Do we need Policy Clearance certificate prior to getting the ITA? Is this required step to complete for initial submission of the profile to get into the queue?
Also, I am planning to include spouse as part of the application. In that case, do i need to get PCC for my wife also?
You would need PCC for every country you stayed for more than 6 months, If you are including your spouse - you will need PCC for her as well.
For ITA , you dont need PCC but post ITA you would need, you can start the process now so that by the time you get ITA you will have everything ready.
You can check this thread , it is a wiki for most of the common questions.